Course: Toxicology

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Course title Toxicology
Course code KCH/TOX
Organizational form of instruction Lecture
Level of course Bachelor
Year of study 3
Semester Winter
Number of ECTS credits 2
Language of instruction Czech
Status of course Compulsory, Optional
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Lecturer(s)
  • Richtr Václav, Doc. Mgr. CSc.
  • Zloch Zdeněk, Doc. Ing. CSc.
Course content
1st-2nd lecture Biochemical markers of poisonings. The main discipline of toxicology. Entering channel of nox into the organism, the possibilities of prevention. Therapeutic extensity, toleration, poison addictiveness. The main kinetic parameters of metabolism and poison excretion, compartmen meaning; the dependence of the effects upon dose and concentration of poison. The main types of nox target effects on the organism. Median lethal dose, minimum lethal dose, maximum permissible concentrations, acceptable daily dose of poison, cumulation coefficient. QSAR. 3rd lecture Standard methods of toxicity testing and substance mutagenicity. Biological exposure tests. Two phases of biotransformation. 4th lecture Health harmfulness of the elements C, Si, Pb, nitrogen compound. Health harmfulness of P, As, Sb, Bi. 5th lecture Health harmfulness of oxygen, free oxygen radicals and peroxides. 6th lecture Health harmfulness of sulfur and selenium. Toxicology of fluorine, chlorine, bromine, jodine and their compounds. 7th lecture Health harmfulness of copper and silver. Toxicology of zinc, cadmium, mercury, chromium, manganese, cobalt, iron, nickel. 8th lecture Health harmfulness and dangerousness of aliphatic hydrocarbons. Health harmfulness and danderousness of aromatic hydrocarbons. 9th lecture Toxicity of ethanol and methanol. Toxicology of glycol, phenols, cresols. 10th lecture Toxicity of aliphatic halogenated hydrocarbons, nitro-, amino- and hydrazine derivatives of hydrocarbons. Health harmfulness of aldehydes and ketones. Toxicology of esters of inorganic and organic acids. 11th lecture Toxicologal charakteristics of radioactive substances. Definition of poisons, corrosive substances, narcotic and psychotropic substances; the principles of gaining and storage of poisons. 12th The principles of work with poisons. Definition and classification of combustible. The principles of giving first aid for chemical poisoning. First aid for chemical burns and burns, for eye injury.

Learning activities and teaching methods
Self-study of literature, Lecture
  • Contact hours - 26 hours per semester
  • Preparation for an examination (30-60) - 30 hours per semester
prerequisite
professional knowledge
charakterizovat základní metabolické procesy
charakterizovat jednotlivé typy chemických sloučenin
charakterizovat typy chemických reakcí
orientovat se v dostupné literatuře
professional skills
vyhodnotit kvalitativní a kvantitativní složení zkoumaných systémů
pracovat s dostupnou literaturou a elektronickými zdroji
learning outcomes
professional knowledge
vysvětlit toxicitu jednotlivých prvků a chemických sloučenin
klasifikovat produkty lidské činnosti na základě znalosti toxikologických vlastností látek
professional skills
posoudit nebezpečnost toxických látek pro chování a rozvoj člověka
aplikovat teoretické znalosti z oboru toxikologie do praxe
teaching methods
professional knowledge
Lecture
Self-study of literature
assessment methods
Combined exam
Recommended literature
  • Horák, Josef. Ekologická rizika spojená s výrobou a použitím chemických látek a ochrana proti nim. Ostrava : Vysoká škola báňská - Technická univerzita Ostrava, 1996. ISBN 80-7078-369-9.
  • Jílek, T. Vybrané kapitoly z toxikologie I, II. Plzeň, 1998.
  • Kvasničková E. Xenobiochemie. UK Praha, 1996.
  • Prokeš J. a kol. Základy toxikologie I. a II.. Karolinum Praha, 1997.
  • Tichý, Miloň. Toxikologie pro chemiky : toxikologie obecná, speciální, analytická a legislativa. 1. vyd. Praha : Karolinum, 1998. ISBN 80-7184-625-2.


Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Education Chemistry in Education (17) Chemistry courses 3 Winter
Faculty of Education SS Teacher Training in Chemistry (14) Pedagogy, teacher training and social care 1 Winter
Faculty of Education Chemistry in Education (13) Chemistry courses 3 Winter
Faculty of Education BS Teacher Training in Chemistry (16) Pedagogy, teacher training and social care 1 Winter
Faculty of Applied Sciences Training Teachers of Mathematics at Higher Secondary Scholls (2015) Pedagogy, teacher training and social care 1 Winter
Faculty of Education Chemistry in Education (15) Chemistry courses 3 Winter
Faculty of Education SS Teacher Training in Chemistry (16) Pedagogy, teacher training and social care 1 Winter
Faculty of Applied Sciences Training Teachers of Mathematics at Higher Secondary Scholls (2016) Pedagogy, teacher training and social care 1 Winter
Faculty of Education Chemistry in Education (14) Chemistry courses 3 Winter
Faculty of Education SS Teacher Training in Chemistry (1) Pedagogy, teacher training and social care 1 Winter
Faculty of Applied Sciences Training Teachers of Mathematics at Higher Secondary Scholls (2015) Pedagogy, teacher training and social care 1 Winter
Faculty of Education Chemistry in Education (16) Chemistry courses 3 Winter
Faculty of Education Chemistry in Education (17) Chemistry courses 2 Winter
Faculty of Education SS Teacher Training in Chemistry (15) Pedagogy, teacher training and social care 1 Winter
Faculty of Education BS Teacher Training in Chemistry (15) Pedagogy, teacher training and social care 1 Winter
Faculty of Applied Sciences Training Teachers of Mathematics at Higher Secondary Scholls (2016) Pedagogy, teacher training and social care 1 Winter
Faculty of Applied Sciences Training Teachers of Mathematics at Higher Secondary Scholls (2014) Pedagogy, teacher training and social care 1 Winter
Faculty of Education BS Teacher Training in Chemistry (17) Pedagogy, teacher training and social care 1 Winter