Course: Bone metabolism

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Course title Bone metabolism
Course code KAZ/KOST
Organizational form of instruction Lecture
Level of course Bachelor
Year of study not specified
Semester Winter
Number of ECTS credits 1
Language of instruction Czech
Status of course unspecified
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Course availability The course is available to visiting students
  • Pikner Richard, MUDr. Ph.D.
Course content
Interdisciplinary characteristics - laboratory results interpretation viewed and needed for clinical practice and mutual influence. Lectures: 1.Physiology of calcium phosphate metabolism - calcium, phosphor and magnesium regulation axis parathormone PTH - calcitonin - vitamin D, Ca2+ sensing receptor, FGF23. 2.Disorders of calcium phosphate metabolism - hypercalcaemia, hypocalcaemia, hyperphosphatemia, hypophosphatemia, renal-bone disease, hyperparathyroidism, hypoparathyoridism. 3.Laboratory methods of calcium phosphate metabolism - preanalytics, analytics and bases of interpretation - setting of Ca, P, Mg in serum and blood, PTH, vitamin D, calcitonin, PTHrP, FGF23, reference limit, bases of interpretation. 4.Bone remodeling and its regulation - humoral regulations (sex steroids, parathormon, vitamin D, calcitonin, IGF), local regulations (Osteoprotegerin-RANKL, osteocyt-osteoblast-osteoclast and their cell-to-cell interaction). 5.Disorders of bone remodeling - osteoporosis, osteomalacia, Paget's disease, bone metastases, glucocorticoid induced osteoporosis, sclerosing and dysplastic bone diseases. 6.Laboratory methods of bone remodelling disorders investigation - bone remodeling markers, preanalytic, analytic and postanalytic aspects, genetic testing. 7.Practical operation of the bone metabolism surgery closely connected to clinical laboratories. - Bone quality and fracture risks, indications and performing of bone densitometry. Harvesting in bone surgeries - coordination of laboratory investigation requirements with laboratory.

Learning activities and teaching methods
  • Contact hours - 11 hours per semester
  • Preparation for comprehensive test (10-40) - 15 hours per semester
professional knowledge
No particular prerequisites specified.
learning outcomes
A student acquires general knowledge of diagnostic difficulties, bone metabolism disease treatment, primarily in connection with influence in preanalytic and analytic phases with bases of interpretation in the postanalytic phase.
teaching methods
assessment methods
Recommended literature
  • Klinická biochemie a metabolizmus, nakladatelství ČLS JEP.
  • Osteologický bulletin, nakladatelství TRIOS.
  • Racek, J. Klinická biochemie. Galén Praha, 2006.
  • Vyskočil, V. Osteoporóza a ostatní nejčastější metabolická onemocnění skeletu. Galén, 2009.

Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester