Course: Genetic Toxicology

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Course title Genetic Toxicology
Course code KAZ/GETO
Organizational form of instruction Lecture
Level of course Bachelor
Year of study not specified
Semester Winter and summer
Number of ECTS credits 2
Language of instruction Czech
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
  • Polendová Daniela, MUDr.
  • Jaklová Radka, MUDr.
Course content
1. Introduction to the specialisation, teaching syllabus, literature for the course, requirements for the exam, the role of genetic medicine, methods in genetics, findings in the research of external environment factors with genetic toxicity and their relation to the forming of the specialisation. 2. Basics of heredity, classification of hereditary diseases 3. Basic classification of congenital defects related to the genetic etiology and consequently to the possible influence of genetically toxic environment. 4. Cytogenetics, karyotypes, basic analytical methods, chromosomal changes triggered by genetically toxic substances. 5. Molecular genetics, genetic toxicity and DNA, the structure of DNA, reparation of DNA. 6. Basic types of congenital and acquired chromosomal aberrations as a consequence of influence of genetically toxic substances. 7. Somatic and embryonic mutations, mutagenic factors and genetic toxicity. 8. Carcinogenesis, genetically toxic factors supporting the onset of malignant growth. 9. The outline of the most frequent malignant syndromes caused by genetic toxicity. 10. Genetic testing, genetic prognosis, contemporary findings and trends. 11. Teratogens as genetically toxic factors in the living and working environment, teratogenity. 12. Genetically toxic influence of teratogens in pre-natal care. 13. Genetic advisory and assessment of risks of genetic toxicity of the environment. 15. Monitoring of influence of factors of the living and working environment with genetic toxicity, possibilities of prevention. 14. System of genetic advisory service in the Czech Republic, consultations, preparation for the credit test.

Learning activities and teaching methods
Lecture supplemented with a discussion, Lecture with practical applications, Group discussion, Textual studies
  • Preparation for comprehensive test (10-40) - 22 hours per semester
  • Contact hours - 30 hours per semester
professional knowledge
No particular prerequisites specified.
learning outcomes
After completion of the course the student possesses working knowledge of genetic subjects and is able to analyse the impact of genetically toxic substances on the organism.
teaching methods
Lecture supplemented with a discussion
Textual studies
Group discussion
Lecture with practical applications
assessment methods
Recommended literature
  • Dobiáš L., Černá M. Genetická toxikologie a ochrana biosféry.
  • Michalová K. Úvod do lidské cytogenetiky. IDVFP Brno , 1999.
  • Thompson, T. Klinická genetika. Praha, Triton , 2004.

Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Health Care Studies Assistant of Protection and Support of Public Health (2016) Health service 3 Winter
Faculty of Health Care Studies Assistant of Protection and Support of Public Health (2012) Health service 3 Winter