Course: Biology and Medical Genetics

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Course title Biology and Medical Genetics
Course code KAZ/BLG
Organizational form of instruction Lecture
Level of course Bachelor
Year of study not specified
Semester Winter
Number of ECTS credits 3
Language of instruction Czech
Status of course Compulsory
Form of instruction Face-to-face
Work placements This is not an internship
Recommended optional programme components None
Course availability The course is available to visiting students
Lecturer(s)
  • Beránek Václav, Mgr. et Mgr.
Course content
Organisation of living systems. Theory of systems and principle of hierarchic systems. Molecular and cellular biology. Eukaryon and prokaryon cells. Biopolymeres ? proteins. Biopolymeres ? nucleous acids: RNA and DNA ? polysacharids. Memory system of the cell ?gene, structure of gene, non-gene DNA. Hybridisation of DNA. Cellular genome in prokaryons and eukaryons. DNA, histones, acidic proteins. Chromosomes. Nucliolus. Plasmides. Expression of genetic information. Transcription. Post-transcription make-up of RNA. Translation. Ribosomes. Transfer RNA. Regulation of gene expression in eukaryons and prokaryons. Duplication of genetic memory. Noise in genetic information. Genotoxins. Types of gene mutations. Types of chromosome aberrations. Membrane principle of functional organisation of the cell. Plasmatic membrane and membrane transfer. Active transfer ? endocytosis and exocytosis. Membrane receptors, chemoreception, photoreception; Endoplasmatic reticulum, Golgi aparatus, lysosomes, peroxisomes, mitochondries, chloroplasts. Cytoskeleton. Microtubules and microfilamentae. Molecule motors. Motion cellular functions. Nuclear and membrane skeleton of the cell. Exoskeleton. Reproduction of cells ? cell cycle, its phases and its regulation. Mitosis. Differentiation of cells. Tumorous transformation of the cell. Origin and development of tumours. Programmed death of the cell. Cellular stress ? influence of temperature, radiation, ionizing radiation, poisons. Biologie of viruses. Vertical transfer of genetic information in multicellular organisms. Sexual and non-sexual reproduction. Meiosis. Cytoplasmatic heredity. Ontogenesis and spermatogenesis. Fertilization. Genetic regulation of ontogenesis, differentiation of cells. Homeotic genes and homeoboxes. Morphological defects. Teratogenic influence of environment. Laws of vertical transfer of genetic information. Genotype anf phenotype. Dominance and recession. Monogenia and polygenia. Alleles and multiple allelia. Mendel?s laws. Autosomic and gonosomic heredity. Dominance, recession, co-dominance, semi-dominance, gene bond. Letal alleles. Polygenic heredity. Interaction of genotype and environment. Human genome genealogical method, population study. Human cytogenetics and its investigation methods. Heredity of specifically human signs. Autosomal and gonosomal heredity. Immunogenetics. Genetical conditionning of human behaviour. Hereditary diseases of humans ? autosomally dominant and recessive, gonosomally dominant and recessive. Polygenic diseases and defects. Genetic councelling. Prenatal investigation and prevention of defects and hereditary diseases. Chromosome defects in humans. Structural and numerical aberration of human chromosomes. Major chromosome syndroms. Molecular genetic diagnostics of human diseases and the main investigation methods. Genetic therapy and genetic engineering. Bases of population genetics. Global ecology. Eco-genetics. Pharmaco-genetics. Evolution of living systems. Origin of life on the Earth. Reconstruction of the evolution and evolutional mechanisms of living systems. The evolution of man.

Learning activities and teaching methods
Lecture supplemented with a discussion, Multimedia supported teaching
  • Contact hours - 30 hours per semester
  • Preparation for comprehensive test (10-40) - 20 hours per semester
  • Preparation for an examination (30-60) - 28 hours per semester
prerequisite
professional knowledge
No particular prerequisites specified.
learning outcomes
The students will understand basic biological processes in the cell and in the multicellular organism. They will be able to explain basic laws of genetic transfer and the impact of exterior factors on the cell and multicellular organisms; to inform about laws of transfer of genetically conditionned defects and diseases and to start in practice from ecological laws.
teaching methods
Lecture supplemented with a discussion
Multimedia supported teaching
assessment methods
Oral exam
Test
Recommended literature
  • Goetz P. a kol.. Vybrané kapitoly z lékařské biologie II.skriptum UK 2.LF. Praha, Karolinum, 2002.
  • Hájek Z., Kulovaný E., Macek M. Základy prenatální diagnostiky. Grada, 2000. ISBN 80-7169-391-X.
  • Nečas O. a kol. Obecná biologie pro lékařské fakulty,3.vydání. Jinočany, 2000. ISBN 80-86022-46-3.
  • Šmarda J. Genetika pro gymnázia. Fortuna, 2003. ISBN 80-7168-851-7.
  • Thompson and Thompson. Klinická genetika.vydání. Triton, 2004. ISBN 80-72254-475-6.


Study plans that include the course
Faculty Study plan (Version) Branch of study Category Recommended year of study Recommended semester
Faculty of Health Care Studies Assistant of Protection and Support of Public Health (2016) Health service 1 Winter